ANTI VIRALAND IMMUNOMODULATORY BIOACTIVE COMPOSITION
(Postulated to be most prolific in SARS-CoV 2)
Man’s existence on this earth has been made possible only because of the vital role played by the plant kingdom in sustaining his life. Without the variety of living organisms that makes up the World of plants, animal life would not survive and our planet would have been a barren and lifeless World of deserts. The nature has showered a complete store-house of remedies to cure all ailments of mankind. Since the dawn of civilization, in addition to food crops, man cultivated herbs for his medicinal needs. The knowledge of drugs has accumulated over thousands of years as a result of man’s inquisitive nature. The human beings appear to be afflicted with more diseases than any other animal species.
Tropical forest plants have served as a source of medicines for people of the tropics for millennia. We are well aware of the number of modern therapeutic agents that have been derived from tropical forest species. It is a fact of history that around 120 pharmaceutical products have been derived from plants and some 75% of these were discovered by examining the use of these plants in traditional medicine.
DEFINITION OF VIRUS:
Viruses are very small infectious agents. They’re made up of a piece of genetic material, such as DNA or RNA, that’s enclosed in a coat of protein. Viruses invade cells in your body and use components of those cells to help them multiply. This process often damages or destroys infected cells. A viral disease is any illness or health condition caused by a virus.
To put these historical facts into perspective, the World Health Organization reports that 74% of at least 119 phytomedicines are still used in modern medicine in a manner which corresponds directly with their use as traditional medicines by various native cultures
Common Symptoms in Viral Infection:
• Fever (but not always)
• Sore throat
• Runny or stuffy nose
• Watery, red eyes
• Body aches
• Nausea and vomiting
• Loss of Smell
• Loss of Taste
PRESENT PANDEMIC:: SARS-COVID 2: – Pathogenesis:
The corona Virus, though not “Pandemic” but has opened its deadly wings in series of Countries, which alarming.
During infection with corona viruses, as with all other RNA viruses, replication of genome and transcription of mRNAs must occur. Replication of the genome involves the synthesis of a full-length negative-strand RNA that is present at a low concentration and serves as template for full-length genomic RNA.
The current model is that discontinuous transcription occurs during the synthesis of subgenomic negative-strand RNAs, with the antileader sequences being added onto the 3′ ends of negative-strand RNAs which then serve as templates for synthesis of mRNAs Corona viruses attach to specific cellular receptors via the spike protein
The heptad repeat domains and the putative fusion peptide are believed to play important roles in the fusion process
SARS infection exhibits a wide clinical course, characterized mainly by fever, dyspnoea, lymphopenia, and lower respiratory tract infection like other RNA viruses; all corona viruses encode, in addition to structural proteins and replicase proteins, small nonessential proteins of unknown function.
In addition to its role as structural protein, N protein plays a role in transcription and also in pathogenesis. Expression of N protein is necessary for efficient recovery of virus from infectious cDNA clones and recently has been shown to enhance the replication of HCoV-229E genome RNA.
The M protein (Membrane Protein) is the most abundant virion membrane protein. Aside from its role in viral assembly, the coronavirus M protein is believed to have functions in host interactions. It may be O glycosylated (groups I and III) or N glycosylated (group II). While glycosylation is not essential for viral assembly or infectivity, the glycosylation state of M protein is likely to play a role in virus-host interaction.
Nationally and internationally well established and justified ingredients and formulation has following prolific affects:
1. Suppressing nuclear factor kappa beta (NF-KB). Cancer cells often
Over-express NF-KB and use this as a means to proliferate. ———–
has been shown to suppress NF-KB.
2. Blocking cancer-mimicking chemicals that promote cancer growth.
——— blocks estrogen and estogen-mimicking chemicals that promote
cell mutation and proliferation. These chemicals are found in our
Environment and are encounctered daily and include paraquat, a weed
killer, notrosamines in cooked and “lunch” meats, carbon tetrachloride
(a solvent found in paints and other products).
3. Suppressing inflammation inherent in certain forms of cancer. C…..
inhibits cyclooxygenase (COX) and lipoxygebnaise (LOX), two enzymes
that promote inflammation believed to play a significant role in the
development and progression of cell carcinoma and colon cancer.
4. A Strong Antioxidant. C——- protects our cells against free radicals
that promote cancer and cause aging by damaging DNA and activating
genes. In a recent laboratory study, ———– protected bacteria from a
lethal dose of radiation almost flawlessly.
5. Destroying Abnormal Pre-cancerous Cells. Stops certain forms of cancer
by inducing “aptosis,” a process that identifies cancerous cells and instructs
them to self-destruct.
6. Stopping Cancer Cells from Multiplying. Stops the growth of cancer cells
in the advanced stages of cancer development.
7. Enhancing Immunity Shown to stimulate both localized and general
immunity including CD4 + T-helper and By type immune cells.
8. Inhibiting Angiogenesis, or the process by which tumors create their own
blood supply. ————- inhibits the enzyme critical to the process and by
blocking iron and copper from the bloodstream, which are required for the
growth of blood vessels that the tumors require.C———— inhibits
Chemotherapy-induced apoptosis in models of human breast Cancer
9. U ——- ——- Inhibits Nuclear Factor- B Activation Induced by Carcinogenic Agents through Suppression of I B Kinase and p65 Phosphorylation
10. U——— ——- Inhibits TNF-induced Nuclear Translocation of p65:
11. U——— ———- In habits TNF-induced COX-2, MMP-9, and Cyclin D1
12. U——- —— produced apoptotic bodies and DNA fragmentation.
U———————– enhanced transcriptional activity of p53.
U————– ———– increased activation of p53 and expression of apoptotic Proteins.
13. Therapetic Indication: Analgesic, Anti-Inflammatory, Anti-Bacterial, Anti-periodic, Anti-Malarial, Anti-Thrombotic, Anti-Viral, Anti-Cancer, Hepatoprotective, Hypoglycemic, Immunostimulant, Anti-HIV.
14. Immunostimulant agents
15. A———- has been used to treat tonsillitis, respiratory infections, and tuberculosis.
16. Inhibitory effect of A—–L from A—— —— on PAF-induced platelet aggregation.
17. Antiviral Agents
Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly.
18. HMPL-004 acts on multiple cellular targets in the inflammatory signal transduction pathways resulting in suppressed inflammation cytokine expression including TNF-α, IL-1β and IL-6. HMPL-004 was demonstrated to inhibit TNF-α and IL-1β production in cell-based assays. HMPL-004 is also able to inhibit NF-kB activation. NF-kB is a family of transcriptional factors that regulate a wide spectrum of genes critically involved in host defense and inflammation. The mechanism of action of HMPL-004 was further supported in laboratory IBD animal models. Treatment of IBD rats with HMPL-004 caused a significant drop in plasma cytokine concentrations, including TNF-α and IL-1β.
1. Stimulates gamma-glutamyl transpeptidase activity and causes an increase in amino acid uptake by epithelial cells
2. Enhances gastrointestinal blood flow which causes increased absorption of drugs from the digestive tract. . Increased permeability due to epithelial cell modification:
3. Increases permeability at the site of absorption by modulating lipid environment and membrane dynamics.
4. Increases the stay of a drug at the active site by inhibiting human p-glycoprotein, which is a major efflux pump. Inhibition of solubilizer attachment When substances are chemically linked to a highly water soluble substance, their entry in the cells is prevented.
5. Possess superior anti-HBV activity in vitro.
6. ———— exerts BaP-induced cytotoxicity in V-79 lung fibroblast cells, due to a decrease in GST and UDP-GT